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Developmental and extracellular matrix-remodeling processes in rosiglitazone-exposed neonatal rat cardiomyocytes_TS

ABSTRACT: The objective of this study was to investigate the effects of rosiglitazone (Avandia) on gene expression in neonatal rat ventricular myocytes. Myocytes were exposed to rosiglitazone ex vivo. The two factors examined in the experiment were drug exposure (r

ORGANISM(S): Rattus norvegicus

SUBMITTER: Gary Hardiman

PROVIDER: E-MTAB-2426 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Developmental and extracellular matrix-remodeling processes in rosiglitazone-exposed neonatal rat cardiomyocytes.

Paolini Paul P Pick Daniel D Lapira Jennifer J Sannino Giuseppina G Pasqualini Lorenza L Ludka Colleen C Sprague L James LJ Zhang Xian X Bartolotta Elesha A EA Vazquez-Hidalgo Esteban E Barba David Torres DT Bazan Carlos C Hardiman Gary G

Pharmacogenomics 20140401 6

<h4>Objective</h4>The objective of this study was to investigate the effects of rosiglitazone (Avandia(®)) on gene expression in neonatal rat ventricular myocytes.<h4>Materials & methods</h4>Myocytes were exposed to rosiglitazone ex vivo. The two factors examined in the experiment were drug exposure (rosiglitazone and dimethyl sulfoxide vs dimethyl sulfoxide), and length of exposure to drug (½ h, 1 h, 2 h, 4 h, 6 h, 8 h, 12 h, 18 h, 24 h, 36 h and 48 h).<h4>Results</h4>Transcripts that were cons ...[more]

PMID: 24897284

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