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LSCC

ABSTRACT: The basaloid carcinoma (pure) and the (mixed) basalod variant of lung squamous cell carcinoma (SCC) have a dismal prognosis but their underlying specific molecular characteristics remain obscure and no therapy has proven to be efficient. In order to assess their molecular specificity among other lung squamous cell carcinomas we analysed DNA copy number aberrations and mRNA expression pangenomic profiles of 93 SCC, including 42 basaloid samples (24 pure, 18 mixed).

ORGANISM(S): Homo sapiens

SUBMITTER: Nabila Elarouci

PROVIDER: E-MTAB-2435 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Lung squamous cell carcinomas with basaloid histology represent a specific molecular entity.

Brambilla Christian C Laffaire Julien J Lantuejoul Sylvie S Moro-Sibilot Denis D Mignotte Hélène H Arbib François F Toffart Anne-Claire AC Petel Fabien F Hainaut Pierre P Rousseaux Sophie S Khochbin Saadi S de Reyniès Aurélien A Brambilla Elisabeth E

Clinical cancer research : an official journal of the American Association for Cancer Research 20140904 22

<h4>Purpose</h4>The basaloid carcinoma (pure) and the (mixed) basaloid variant of lung squamous cell carcinoma (SCC) have a dismal prognosis but their underlying specific molecular characteristics remain obscure and no therapy has proven to be efficient.<h4>Experimental design</h4>To assess their molecular specificity among other lung SCCs we analyzed DNA copy number aberrations and mRNA expression pangenomic profiles of 93 SCCs, including 42 basaloid samples (24 pure, 18 mixed).<h4>Results</h4> ...[more]

PMID: 25189482

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