Unknown,Transcriptomics,Genomics,Proteomics

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Dynamic liver transcriptome response of Xenopus tropicalis to benzo[a]pyrene


ABSTRACT: Chronological RNA-seq of comparison of liver from xenopus tropicalis exposed or not to benzo[a]pyrene (10ᄉg/L)

INSTRUMENT(S): Illumina Genome Analyzer II

ORGANISM(S): Xenopus tropicalis

SUBMITTER: Stephane Reynaud 

PROVIDER: E-MTAB-2444 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Impaired liver function in Xenopus tropicalis exposed to benzo[a]pyrene: transcriptomic and metabolic evidence.

Regnault Christophe C   Worms Isabelle A M IA   Oger-Desfeux Christine C   MelodeLima Christelle C   Veyrenc Sylvie S   Bayle Marie-Laure ML   Combourieu Bruno B   Bonin Aurélie A   Renaud Julien J   Raveton Muriel M   Reynaud Stéphane S  

BMC genomics 20140808


<h4>Background</h4>Despite numerous studies suggesting that amphibians are highly sensitive to cumulative anthropogenic stresses, the role pollutants play in the decline of amphibian populations remains unclear. Amongst the most common aquatic contaminants, polycyclic aromatic hydrocarbons (PAHs) have been shown to induce several adverse effects on amphibian species in the larval stages. Conversely, adults exposed to high concentrations of the ubiquitous PAH, benzo[a]pyrene (BaP), tolerate the c  ...[more]

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