Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of peripheral blood leukocyte subsets in autoimmune/autoinflammatory disease patients and healthy controls


ABSTRACT: Gene expression microarray profiling was performed on peripheral blood leukocyte subsets (CD4+ T cells, CD14+ monocytes, and CD16+ neutrophils) from healthy controls and patients with flaring autoimmune disease.

ORGANISM(S): Homo sapiens

SUBMITTER: Arianne Richard 

PROVIDER: E-MTAB-2452 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Comparison of gene expression microarray data with count-based RNA measurements informs microarray interpretation.

Richard Arianne C AC   Lyons Paul A PA   Peters James E JE   Biasci Daniele D   Flint Shaun M SM   Lee James C JC   McKinney Eoin F EF   Siegel Richard M RM   Smith Kenneth G C KG  

BMC genomics 20140804


<h4>Background</h4>Although numerous investigations have compared gene expression microarray platforms, preprocessing methods and batch correction algorithms using constructed spike-in or dilution datasets, there remains a paucity of studies examining the properties of microarray data using diverse biological samples. Most microarray experiments seek to identify subtle differences between samples with variable background noise, a scenario poorly represented by constructed datasets. Thus, microar  ...[more]

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