Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

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Proj022_chipseq


ABSTRACT: The mechanisms that recruit the major Polycomb-group (PcG) complexes PRC1 and PRC2 to target sites in vertebrate cells are not well understood. Building on recent studies that have determined a reciprocal relationship between DNA methylation and Polycomb activity, we demonstrate that in methylation deficient ES cells CpG density, combined with antagonistic effects of H3K9me3 and H3K36me3, redirect PcG complexes to pericentric heterochromatin and gene rich domains. In this experiment we have assayed the genomic distribution of H3K9me3 and H3K36me3 marks,

INSTRUMENT(S): Illumina HiSeq 2000

ORGANISM(S): Mus musculus

SUBMITTER: Andreas Heger 

PROVIDER: E-MTAB-2481 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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