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MoMaTEC1403

ABSTRACT: Aim for investigation of expression patterns of endometrial cancers

ORGANISM(S): Homo sapiens

SUBMITTER: Ingvild Tangen1,2*

PROVIDER: E-MTAB-2532 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Switch in FOXA1 status associates with endometrial cancer progression.

Tangen Ingvild Løberg IL Krakstad Camilla C Halle Mari K MK Werner Henrica M J HM Oyan Anne M AM Kusonmano Kanthida K Petersen Kjell K Kalland Karl Henning KH Akslen Lars A LA Trovik Jone J Hurtado Antoni A Salvesen Helga B HB

PloS one 20140521 5

<h4>Background</h4>The transcription factor Forkhead box A1 (FOXA1) is suggested to be important in hormone dependent cancers, although with little data for endometrial cancer. We investigated expression levels of FOXA1 in primary and metastatic endometrial cancer in relation to clinical phenotype, and transcriptional alterations related to FOXA1 status.<h4>Methods</h4>Protein expression of FOXA1 was explored by immunohistochemistry in 529 primary and 199 metastatic endometrial carcinoma lesions ...[more]

PMID: 24849812

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MoMaTEC1606

Project description:Metastatic lesions of endometrial cancer. The data was firstly utilized for identification of highly connected and differentially expressed subnetworks between aggressive primary tumors and metastases. The 66 primary tumor samples have been reused from E-MTAB-2532 using the same prefix (4 digits) of Normalization Name.

2017-12-30 | E-MTAB-5017 | biostudies-arrayexpress

Transcription profiling by array of human prostate carcinoma cells during a stepwise epithelial to mesenchymal transition

Project description:Background: The loss of epithelial characteristics and the acquisition of a migratory phenotype, referred to as epithelial to mesenchymal transition (EMT), is a crucial event in tumor metastasis. A better defined cell culture model for the study of EMT and its role in prostate carcinogenesis has been a challenge. Our previous work reported an EMT model based on primary prostate epithelial cells (EP156T) which gave rise to cells with mesenchymal phenotype (EPT1) without malignant transformation. Here, we present an extension of this model to stepwise malignant transformation in relation to EMT and gene expression reprogramming. Results: To achieve transformed prostate cells, EPT1 cells were kept growing in extended saturation density culture to select for cells overriding quiescence. Foci formed in EPT1 cells in 4 weeks. Cells from the foci can form robust colonies in soft agar suggesting malignant transformation. The transformed cells were named EPT2. In this stepwise transformation model, EPT2 cells showed much higher abilities to proliferation at confluence, higher resistance to apoptosis, and much lower dependence on serum and exogenous growth factors than EP156T and EPT1 cells. When EP156T and EPT1 cells at different passages were compared, only EPT1 cells at later passage but not EP156T cells could be induced to malignant transformation by high density culture. Microarray expression profiling showed that EMT and transformation were strongly connected at the gene expression level, suggesting that EMT makes EPT1 cells at later passage more susceptible to transformation induction. Conclusions: Our findings provide a novel stepwise transformation model in which EMT can emerge not only independent of transformation, but also can promote subsequent malignant transformation in prostate carcinogenesis. Dynamic changes of a core set of genes are involved in both EMT and subsequent malignant transformation.

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Transcriptional profiling of human breast cancer cell lines.

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Transcription profiling of human prostate cell lines to supplement a histone methylation pattern ChIP study

Project description:This experiment supplements the 'Histone Methylation pattern ChIP study' with gene expression profiles. These are analyzed in the light of the methylation patterns discovered.

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Transcription profiling by array of mouse embryo fibroblasts from wild type and sp3 E553D knock in mutants defective for SUMOylation

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Transcription profiling of rat DMBA induced mammary adeno carcinoma

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2009-06-22 | E-TABM-718 | biostudies-arrayexpress

Identification of differentially expressed genes in human alveolar bone cells cultured on different titanium surfaces.

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