Autophagy_deficiency_pancreas
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Kalliope Diakopoulos
PROVIDER: E-MTAB-2635 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Impaired autophagy induces chronic atrophic pancreatitis in mice via sex- and nutrition-dependent processes.
Diakopoulos Kalliope N KN Lesina Marina M Wörmann Sonja S Song Liang L Aichler Michaela M Schild Lorenz L Artati Anna A Römisch-Margl Werner W Wartmann Thomas T Fischer Robert R Kabiri Yashar Y Zischka Hans H Halangk Walter W Demir Ihsan Ekin IE Pilsak Claudia C Walch Axel A Mantzoros Christos S CS Steiner Jörg M JM Erkan Mert M Schmid Roland M RM Witt Heiko H Adamski Jerzy J Algül Hana H
Gastroenterology 20141211 3
<h4>Background & aims</h4>Little is known about the mechanisms of the progressive tissue destruction, inflammation, and fibrosis that occur during development of chronic pancreatitis. Autophagy is involved in multiple degenerative and inflammatory diseases, including pancreatitis, and requires the protein autophagy related 5 (ATG5). We created mice with defects in autophagy to determine its role in pancreatitis.<h4>Methods</h4>We created mice with pancreas-specific disruption of Atg5 (Ptf1aCreex ...[more]
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