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Transcription profiling by array of mouse pachytene cells from mir-34bc+/-;449+/- and mir-34bc-/-;449-/- male animals.

ABSTRACT: Analysis of gene expression (mRNA profiles) from mouse pachytene cells. Mir-34bc+/-;449+/- samples are compared against mir-34bc-/-;449-/- samples .

ORGANISM(S): Mus musculus

SUBMITTER: Marcos Morgan

PROVIDER: E-MTAB-2668 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Oligoasthenoteratozoospermia and infertility in mice deficient for miR-34b/c and miR-449 loci.

Comazzetto Stefano S Di Giacomo Monica M Rasmussen Kasper Dindler KD Much Christian C Azzi Chiara C Perlas Emerald E Morgan Marcos M O'Carroll Dónal D

PLoS genetics 20141016 10

Male fertility requires the continuous production of high quality motile spermatozoa in abundance. Alterations in all three metrics cause oligoasthenoteratozoospermia, the leading cause of human sub/infertility. Post-mitotic spermatogenesis inclusive of several meiotic stages and spermiogenesis (terminal spermatozoa differentiation) are transcriptionally inert, indicating the potential importance for the post-transcriptional microRNA (miRNA) gene-silencing pathway therein. We found the expressio ...[more]

PMID: 25329700

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