Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

Neuroblastoma cell lines


ABSTRACT: Untreated neuroblastoma cell lines SMS-KCN, SMS-KCNR, Kelly, and SH-SY5Y were sequenced on an Illumina GA IIx sequencer.

INSTRUMENT(S): Illumina Genome Analyzer IIx

ORGANISM(S): Homo sapiens

SUBMITTER: David Duffy 

PROVIDER: E-MTAB-2690 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

altmetric image

Publications


Despite intensive study, many mysteries remain about the MYCN oncogene's functions. Here we focus on MYCN's role in neuroblastoma, the most common extracranial childhood cancer. MYCN gene amplification occurs in 20% of cases, but other recurrent somatic mutations are rare. This scarcity of tractable targets has hampered efforts to develop new therapeutic options. We employed a multi-level omics approach to examine MYCN functioning and identify novel therapeutic targets for this largely un-drugga  ...[more]

Similar Datasets

2014-10-01 | E-MTAB-1684 | biostudies-arrayexpress
2015-06-30 | E-MTAB-2689 | biostudies-arrayexpress
2014-12-30 | E-MTAB-2691 | biostudies-arrayexpress
2014-10-02 | E-MTAB-2969 | biostudies-arrayexpress
2019-11-12 | PXD010845 | Pride
2016-10-25 | E-MTAB-4100 | biostudies-arrayexpress
2016-03-02 | E-GEOD-68085 | biostudies-arrayexpress
2024-09-27 | PXD056312 | Pride
2013-08-19 | E-GEOD-44799 | biostudies-arrayexpress
2020-01-06 | E-MTAB-7641 | biostudies-arrayexpress