Ontology highlight
ABSTRACT:
INSTRUMENT(S): Illumina Genome Analyzer IIx
ORGANISM(S): Homo sapiens
SUBMITTER: David Duffy
PROVIDER: E-MTAB-2690 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Duffy David J DJ Krstic Aleksandar A Halasz Melinda M Schwarzl Thomas T Fey Dirk D Iljin Kristiina K Mehta Jai Prakash JP Killick Kate K Whilde Jenny J Turriziani Benedetta B Haapa-Paananen Saija S Fey Vidal V Fischer Matthias M Westermann Frank F Henrich Kai-Oliver KO Bannert Steffen S Higgins Desmond G DG Kolch Walter W
Oncotarget 20151201 41
Despite intensive study, many mysteries remain about the MYCN oncogene's functions. Here we focus on MYCN's role in neuroblastoma, the most common extracranial childhood cancer. MYCN gene amplification occurs in 20% of cases, but other recurrent somatic mutations are rare. This scarcity of tractable targets has hampered efforts to develop new therapeutic options. We employed a multi-level omics approach to examine MYCN functioning and identify novel therapeutic targets for this largely un-drugga ...[more]