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Unknown,Transcriptomics,Genomics,Proteomics

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Neuroblastoma cell lines

ABSTRACT: Untreated neuroblastoma cell lines SMS-KCN, SMS-KCNR, Kelly, and SH-SY5Y were sequenced on an Illumina GA IIx sequencer.

INSTRUMENT(S): Illumina Genome Analyzer IIx

ORGANISM(S): Homo sapiens

SUBMITTER: David Duffy

PROVIDER: E-MTAB-2690 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Integrative omics reveals MYCN as a global suppressor of cellular signalling and enables network-based therapeutic target discovery in neuroblastoma.

Duffy David J DJ Krstic Aleksandar A Halasz Melinda M Schwarzl Thomas T Fey Dirk D Iljin Kristiina K Mehta Jai Prakash JP Killick Kate K Whilde Jenny J Turriziani Benedetta B Haapa-Paananen Saija S Fey Vidal V Fischer Matthias M Westermann Frank F Henrich Kai-Oliver KO Bannert Steffen S Higgins Desmond G DG Kolch Walter W

Oncotarget 20151201 41

Despite intensive study, many mysteries remain about the MYCN oncogene's functions. Here we focus on MYCN's role in neuroblastoma, the most common extracranial childhood cancer. MYCN gene amplification occurs in 20% of cases, but other recurrent somatic mutations are rare. This scarcity of tractable targets has hampered efforts to develop new therapeutic options. We employed a multi-level omics approach to examine MYCN functioning and identify novel therapeutic targets for this largely un-drugga ...[more]

PMID: 26673823

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