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Transcription profiling by array of human breast tumors and adjacent cancer-free tissue to study Bmi-1 and Mel-18 expression

ABSTRACT: A total of 79 breast tumors (71 malignant tumors, 6 fibroadenomas, and 2 DCIS) were studied and compared to the reduction mammoplastic specimens of 12 healthy women as well as adjacent cancer-free tissue for 23 of the malignant tumors. Polycomb Group (PcG) proteins Bmi-1 and Mel-18 were then studied more closely first on mRNA expression level using microarray data from two of our ongoing projects and then on protein expression level using immunohistochemistry.

ORGANISM(S): Homo sapiens

DISEASE(S): invasive ductal carcinoma

SUBMITTER: Margit Riis

PROVIDER: E-MTAB-271 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Expression of BMI-1 and Mel-18 in breast tissue--a diagnostic marker in patients with breast cancer.

Riis Margit L H ML Lüders Torben T Nesbakken Anne-Jorunn AJ Vollan Hilde S HS Kristensen Vessela V Bukholm Ida R K IR

BMC cancer 20101216

<h4>Background</h4>Polycomb Group (PcG) proteins are epigenetic silencers involved in maintaining cellular identity, and their deregulation can result in cancer. Expression of Mel-18 and Bmi-1 has been studied in tumor tissue, but not in adjacent non-cancerous breast epithelium. Our study compares the expression of the two genes in normal breast epithelium of cancer patients and relates it to the level of expression in the corresponding tumors as well as in breast epithelium of healthy women.<h4 ...[more]

PMID: 21162745

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