Leukocyte subset-specific type 1 interferon signatures in SLE and other immune-mediated diseases.

ABSTRACT: Objectives
Type 1 interferons (IFN-I) are implicated in the pathogenesis of systemic lupus erythematosus (SLE), but most studies have only reported the effect of IFN-I on mixed cell populations. We aimed to define modules of IFN-I associated genes in purified leukocyte populations and use these as a basis for a detailed comparative analysis.
Methods
CD4+ and CD8+ T-cells, monocytes and neutrophils were purified from patients with SLE, other immune-mediated diseases and healthy volunteers (HV)and gene expression determined by microarray. Modules of IFN-I associated genes were defined using weighted gene coexpression network analysis. The composition and expression of these modules was analysed.
Results
1,150 of 1,288 IFN-I associated genes were specific to myeloid subsets,

ORGANISM(S): Homo sapiens

SUBMITTER: Richard Coulson 

PROVIDER: E-MTAB-2713 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress