Fibroblasts prepared from stroma of basal cell carcinoma in comparison to normal dermal fibroblasts

ABSTRACT: Adult tissue stem cells are known to participate in cancer formation. Indeed, cells exhibiting markers of embryonic stem cells such as Oct-4 and Nanog were detected in some malignant tumors. In this study we demonstrated that stromal cells prepared from the basal cell carcinoma are able to induce expression of embryonic stem cell markers such as the Oct-4, Nanog and Sox-2 in mouse 3T3 fibroblasts. These stem cell-like elements have the differentiation potential similar to mesenchymal stem cells. They are also able to induce expression of Oct-4 and Nanog in the human hair follicle keratinocytes. Employing the microarray technology, the role of growth factors such as IGF-2, FGF-7, leptin, NGF and TGF-_ produced by stromal fibroblasts was established to be responsible for the biological activity of the fibroblasts.

ORGANISM(S): Homo sapiens

DISEASE(S): basal cell carcinoma, Gorlin-Goltz syndrome

SUBMITTER: Michal Kolar 

PROVIDER: E-MTAB-272 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress