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MiRNA-1/133a clusters regulate adrenergic control of cardiac repolarization

ABSTRACT: Analysis of the function of miR-1/133a clusters in Physiology of the adult heart. Analysis of transcriptome was perfromed for heart tissue isolated from WT (n=7), miR-1-1/133a KO (mouse chromosome 2; n=4) and miR-1-2/133a-1 KO (mouse chromosome 18; n=5) animals.

ORGANISM(S): Mus musculus

SUBMITTER: Thomas Boettger

PROVIDER: E-MTAB-2727 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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MiRNA-1/133a clusters regulate adrenergic control of cardiac repolarization.

Besser Johannes J Malan Daniela D Wystub Katharina K Bachmann Angela A Wietelmann Astrid A Sasse Philipp P Fleischmann Bernd K BK Braun Thomas T Boettger Thomas T

PloS one 20141121 11

The electrical properties of the heart are primarily determined by the activity of ion channels and the activity of these molecules is permanently modulated and adjusted to the physiological needs by adrenergic signaling. miRNAs are known to control the expression of many proteins and to fulfill distinct functions in the mammalian heart, though the in vivo effects of miRNAs on the electrical activity of the heart are poorly characterized. The miRNAs miR-1 and miR-133a are the most abundant miRNA ...[more]

PMID: 25415383

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