Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

RNA-seq of 1019 human cancer cell lines from the Cancer Cell Line Encyclopedia

ABSTRACT: RNA-seq of 1019 human cancer cell lines from the Broad-Novartis Cancer Cell Line Encyclopedia (http://www.broadinstitute.org/ccle). The original annotation of each cell line to a disease has been checked and manually curated by Expression Atlas (https://www.ebi.ac.uk/gxa/home). Note the original version of the dataset contained 934 cell lines. In the latest update, 2 cell lines were removed (presumed duplicates) and 87 added new.

INSTRUMENT(S): Illumina HiSeq 2000

ORGANISM(S): Homo sapiens

SUBMITTER:

PROVIDER: E-MTAB-2770 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

ACCESS DATA

Publications

Next-generation characterization of the Cancer Cell Line Encyclopedia.

Ghandi Mahmoud M Huang Franklin W FW Jané-Valbuena Judit J Kryukov Gregory V GV Lo Christopher C CC McDonald E Robert ER Barretina Jordi J Gelfand Ellen T ET Bielski Craig M CM Li Haoxin H Hu Kevin K Andreev-Drakhlin Alexander Y AY Kim Jaegil J Hess Julian M JM Haas Brian J BJ Aguet François F Weir Barbara A BA Rothberg Michael V MV Paolella Brenton R BR Lawrence Michael S MS Akbani Rehan R Lu Yiling Y Tiv Hong L HL Gokhale Prafulla C PC de Weck Antoine A Mansour Ali Amin AA Oh Coyin C Shih Juliann J Hadi Kevin K Rosen Yanay Y Bistline Jonathan J Venkatesan Kavitha K Reddy Anupama A Sonkin Dmitriy D Liu Manway M Lehar Joseph J Korn Joshua M JM Porter Dale A DA Jones Michael D MD Golji Javad J Caponigro Giordano G Taylor Jordan E JE Dunning Caitlin M CM Creech Amanda L AL Warren Allison C AC McFarland James M JM Zamanighomi Mahdi M Kauffmann Audrey A Stransky Nicolas N Imielinski Marcin M Maruvka Yosef E YE Cherniack Andrew D AD Tsherniak Aviad A Vazquez Francisca F Jaffe Jacob D JD Lane Andrew A AA Weinstock David M DM Johannessen Cory M CM Morrissey Michael P MP Stegmeier Frank F Schlegel Robert R Hahn William C WC Getz Gad G Mills Gordon B GB Boehm Jesse S JS Golub Todd R TR Garraway Levi A LA Sellers William R WR

Nature 20190508 7757

Large panels of comprehensively characterized human cancer models, including the Cancer Cell Line Encyclopedia (CCLE), have provided a rigorous framework with which to study genetic variants, candidate targets, and small-molecule and biological therapeutics and to identify new marker-driven cancer dependencies. To improve our understanding of the molecular features that contribute to cancer phenotypes, including drug responses, here we have expanded the characterizations of cancer cell lines to ...[more]

PMID: 31068700

Publication: 1/2

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Project description:Olfactory ensheathing cells are one of the few central nervous system regenerative cells discovered so far. It is characterized by its lifelong nerve regeneration function, and it can also release a variety of neurotrophic factors and neural adhesion molecules. It is considered to be the glial cell with the strongest myelination ability. Olfactory ensheathing cells and Schwann cells have phenotypes in common, they can promote axon regeneration(R. Doucette, 1995). Olfactory ensheathing cells have the characteristics of Schwann cells and astrocytes, but the overall performance tends to be the former, which has two unique characteristics. First, it exists not only in the peripheral nerves (Schwann cells), but also in the central nervous system (astroglia); second, the olfactory mucosa has the ability to regenerate life-long, including human olfactory ensheathing cells(J. C. Bartolomei and C. A. Greer, 2000). Regeneration is a process in which olfactory ensheathing cells participate in efficient regulation, although the specific mechanism is not yet clear. Olfactory ensheathing cells are different from astrocytes and Schwann cells, but at the same time have the characteristics of these two cells(S. C. Barnett, 2004), like Schwann cells help axon growth, but more than Schwann cells It can make axons grow long distances, that is, it has stronger migration(A. Ramon-Cueto et al., 1998); there are also astrocytes that have a nutritional effect on the survival of neurons and the growth of axons, but olfactory ensheathing cells can also wrap neurons forms myelin sheath to support the growth of nerve processes(R. Devon and R. Doucette, 1992; J. Gu et al., 2019). There are two characteristics that make olfactory ensheathing cells the best choice for the treatment of neurological diseases(S. C. Chiu et al., 2009; J. Kim et al., 2018; M. Abdel-Rahman et al., 2018). Olfactory ensheathing cells are gradually used to treat spinal cord injuries and have shown amazing effects(J. C. Bartolomei and C. A. Greer, 2000; K. J. Liu et al., 2010; R. Yao et al., 2018). Olfactory ensheathing cells that have been used in research are usually derived from the olfactory bulb(E. H. Franssen et al., 2007), but it is easier to obtain olfactory ensheathing cells from the olfactory mucosa in clinical practice(M. Ryszard et al., 2006), so the difference between the olfactory ensheathing cells from the olfactory bulb and the olfactory mucosa There are more and more studies(B. M. U. et al., 2007), and previous studies have shown that they not only have many similar functions, but also have many differences(M. W. Richter et al., 2005; L. Wang et al., 2014; K. E. Smith et al., 2020). Because olfactory ensheathing cells derived from the olfactory bulb are not easy to obtain, olfactory ensheathing cells derived from the olfactory mucosa have become the focus of attention. Although we know that olfactory ensheathing cells from two sources have nerve repair functions, it is not clear why the two different sources of olfactory ensheathing cells have different therapeutic effects. Nicolas G. once studied that the genetic difference between the two cells and found that there are many genes related to wound repair and nerve regeneration(G. Nicolas et al., 2010). We have reason to guess that olfactory ensheathing cells from these two sources will also have a large difference in protein level. Our research group wants to use the current mature transcriptome and proteomic sequencing technologies to explore the difference between olfactory ensheathing cells from the olfactory bulb and olfactory mucosa, and explain why the two sources of olfactory ensheathing cells shows different therapeutic effects, hope to provide a new theoretical basis for future clinical treatment.

Dataset Information

RNA-seq of 1019 human cancer cell lines from the Cancer Cell Line Encyclopedia

Publications

Next-generation characterization of the Cancer Cell Line Encyclopedia.

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