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Transcription profiling by high throughput sequencing of pancreatic islets from LKB1 and AMPK knockout mice

ABSTRACT: RNA-Seq was performed on pancreatic islets from four transgenic mouse strains affecting LKB1 and AMPK. A conditional LKB1 knockout strain was generated. Double conditional knockouts for AMPK alpha1 and AMPK alpha2 were also generated. These conditional strains were crossed with RIP-Cre (driven by rat insulin promoter) or Ins1-Cre mice to generate LKB1 knockout and AMPK double knockout strains.

INSTRUMENT(S): Illumina HiSeq 2000

ORGANISM(S): Mus musculus

SUBMITTER: Timothy Pullen

PROVIDER: E-MTAB-2791 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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