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Peripheral blood gene expression profiles in obese subjects without metabolic syndrome.

ABSTRACT: Background: Understanding molecular basis involved in obesity is a crucial first step in developing therapeutic strategies against excess in body weight gain Objective: The purpose of our study was to assess if obesity possess unique peripheral blood gene expression profiles, in a pilot study.

ORGANISM(S): Homo sapiens

SUBMITTER: Raquel Almansa

PROVIDER: E-MTAB-3017 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Physical activity diminish fatigue and systemic interferon response in multiple sclerosis

Project description:Objective: To evaluate gene expression profiles in multiple sclerosis (MS) patients who improved their fatigue status after a program of physical exercise and to compare them with healthy controls (HC). Methods: A prospective longitudinal study was conducted. Gene expression in whole blood was profiled at baseline in 7 healthy controls and also in 7 fatigued-MS patients. Patients underwent a physical exercise program for 6 months, and their fatigue status and gene expression profiles were again analyzed at the end of this program. Results: MS patients showed a significant activation of genes participating in the systemic interferon response in comparison with healthy controls. Fatigue improved at the end of the physical activity program, and, in parallel, systemic activation of interferon related genes disappeared. Conclusions: Fatigue improvement following an exercise program is associated to down modulation of interferon activity at the systemic level in MS patients. Our results provide a biological basis for the observed benefit of physical exercise in MS.

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