Browse
Submit Data
Databases
API
Help

Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Peripheral blood gene expression profiles in obese subjects without metabolic syndrome.

ABSTRACT: Background: Understanding molecular basis involved in obesity is a crucial first step in developing therapeutic strategies against excess in body weight gain Objective: The purpose of our study was to assess if obesity possess unique peripheral blood gene expression profiles, in a pilot study.

ORGANISM(S): Homo sapiens

SUBMITTER: Raquel Almansa

PROVIDER: E-MTAB-3017 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

ACCESS DATA

Json Xml

Similar Datasets

Physical activity diminish fatigue and systemic interferon response in multiple sclerosis

Project description:Objective: To evaluate gene expression profiles in multiple sclerosis (MS) patients who improved their fatigue status after a program of physical exercise and to compare them with healthy controls (HC). Methods: A prospective longitudinal study was conducted. Gene expression in whole blood was profiled at baseline in 7 healthy controls and also in 7 fatigued-MS patients. Patients underwent a physical exercise program for 6 months, and their fatigue status and gene expression profiles were again analyzed at the end of this program. Results: MS patients showed a significant activation of genes participating in the systemic interferon response in comparison with healthy controls. Fatigue improved at the end of the physical activity program, and, in parallel, systemic activation of interferon related genes disappeared. Conclusions: Fatigue improvement following an exercise program is associated to down modulation of interferon activity at the systemic level in MS patients. Our results provide a biological basis for the observed benefit of physical exercise in MS.

2015-09-27 | E-MTAB-2973 | biostudies-arrayexpress

Systemic gene expression profiles in patients with ventilator-associated pneumonia

Project description:This project was a prospective translational study aimed at evaluating gene expression profiles (GEP) of patients with ventilator-associated pneumonia (VAP) . GEP of VAP were compared with a control group of patients which did not developed ventilator-associated lower respiratory tract infection despite being subjected to mechanical ventilation.

2018-01-31 | E-MTAB-5638 | biostudies-arrayexpress

Intubated patients developing Tracheobronchitis or Pneumonia have distinctive complement system gene expression signatures

Project description:The onset of an infection-specific transcriptional program precedes the clinical diagnosis in patients who developed Ventilator-associated pneumonia (VAP). Ventilator-associated tracheobronchitis (VAT) is another respiratory infection affecting<br><br>outcomes in intubated patients, but interactions between VAT and VAP remains unknown.

2011-11-19 | E-MEXP-3001 | biostudies-arrayexpress

Molecular lung immunopathology of uncumplicated pdm H1N1 pneumonia in mice.

Project description:In this work we generated a no-letal mice model infected with pandemic H1N1 virus in order to study the mechanisms implicated in the resolution of uncomplicated pneumonia by using gene expression profiles of lung tissues.

2017-09-25 | E-MTAB-3866 | biostudies-arrayexpress

Systemic pro-fibrotic and pro-inflammatory response in patients with advanced cirrhosis

Project description:Objective: To evaluate gene expression profiles in patients with advanced cirrhosis compared with healthy controls (HC). Results: Patients with advanced cirrhosis exhibit an unbalanced systemic response involving pro-fibrotic / protective signatures that could be contributing to the pathogenesis of cirrhosis and also to that of the extra-hepatic complications of this disease.

2016-02-14 | E-MTAB-3338 | biostudies-arrayexpress

IBI_Pasteur_Sepsis_blood

Project description:Gene transcription was compared in blood between noninfected mice and infected mice after 6h of intraperitoneal infection by Neisseria meningitidis

2011-11-22 | E-MEXP-3008 | biostudies-arrayexpress

IBI_Pasteur_Sepsis_brain

Project description:Gene transcription was compared in brain between noninfected mice and infected mice after 6h of intraperitoneal infection by Neisseria meningitidis

2011-11-22 | E-MEXP-3014 | biostudies-arrayexpress

Identification of differentially expressed genes in human alveolar bone cells cultured on different titanium surfaces.

Project description:To evaluate mRNA expression profile (transcriptome), we identified mRNAs of osteoblastic cells from human alveolar crest culture in contact with different titanium surfaces: control (polished), nanotextured (polished titanium discs, etching at 25oC with 50% H2SO4conc and 50% H2O2aq) , nano+submicrotextured (polished titanium discs, etching at 50oC with 50% H2SO4conc and 50% H2O2aq) and rough microtexture (polished titanium discs, etching at 50oC with 100% H2O2aq). The osteoblastic cells were cultured in the alpha-minimum essential medium, supplemented with fetal bovine serum, gentamicin, fungizone, dexamethasone, ascorbic acid and β-glycerophosphate. The mRNA expression profiling was analyzed through hybridizations with whole-human genome Agilent microarray (4x44K format).

2014-11-14 | E-MTAB-3091 | biostudies-arrayexpress

Identification of differentially expressed microRNA in human alveolar bone cells cultured on different titanium surfaces.

Project description:To evaluate miRNA expression profile (miRNOME), we identified microRNAs of osteoblastic cells from human alveolar crest culture in contact with different titanium surfaces: control (polished), nanotextured (polished titanium discs, etching at 25°C with 50% H2SO4conc and 50% H2O2aq) , nano+submicrotextured (polished titanium discs, etching at 50°C with 50% H2SO4conc and 50% H2O2aq) and rough microtexture (polished titanium discs, etching at 50°C with 100% H2O2aq). The osteoblastic cells were cultured in the alpha-minimum essential medium, supplemented with fetal bovine serum, gentamicin, fungizone, dexamethasone, ascorbic acid and β-glycerophosphate. The microRNA expression profiling was analyzed through hybridizations with Agilent miRNA-microarray (8x15K format).

2014-12-12 | E-MTAB-3093 | biostudies-arrayexpress

Transcription profiling by array of lymphocytes from actue lymphoblastic leukemia patients immediately after total body irradation

Project description:To identify genes and related pathways that are regulated by radiotherapy in acute lymphoblastic leukemia (ALL) patients lymphocytes, we have employed whole genome microarray expression profiling as a discovery platform to identify genes associated with total body irradiation (TBI) therapy. Purified peripheral lymphocytes were sampled 24 h after each 4.5 Gray TBI treatment (total 9 Gray) from 4 adult patients receiving hematopoietic stem cell transplantation, and the results showed that 478 genes were differentially expressed with increasing TBI dose, and serial test of cluster (STC) analysis suggested three major patterns in these genes. Modulated genes were constructed to co-expression network and identified significant GO as follow: ubiquitin-dependent protein catabolic process, transcription, proteolysis and apoptosis et al. The reliability of the data obtained from the microarray was verified by performing quantitative real-time PCR on 12 representative genes. This study provides candidate genes associated with TBI sensitivity for further research.

2011-10-27 | E-MEXP-2964 | biostudies-arrayexpress

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data