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Study the histone H3 lysine 9 trimethylation (H3K9me3) in adenoid cystic carcinoma cell lines (ACC) via ChIP-chip by array

ABSTRACT: Chromatin immunoprecipitation on microarrays (ChIP-chip) has been widely used to investigate the DNA binding sites for a variety of proteins such as histone and transcription factors on a genome-wide scale. The purpose of this study is to evaluate the status of histone H3 lysine 9 trimethylation in salivary gland adenoid cystic carcinoma.

ORGANISM(S): Homo sapiens

SUBMITTER: Ronghui Xia 

PROVIDER: E-MTAB-3053 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Low expression of endothelin receptor B (EDNRB) is related to H3K9me3 binding with the EDNRB promoter region and is associated with the clinical T tumor stage in salivary adenoid cystic carcinoma.

Xia Rong-Hui RH   Wang Zhen Z   Zhang Chun-Ye CY   Hu Yu-Hua YH   Zhou Rong-Rui RR   Wang Li-Zhen LZ   Tian Zhen Z   Li Jiang J  

Oral surgery, oral medicine, oral pathology and oral radiology 20150513 2

<h4>Objective</h4>To investigate the endothelin receptor B (EDNRB) expression in salivary adenoid cystic carcinoma (ACC) and the mechanism of the regulation of EDNRB expression.<h4>Study design</h4>After screening, EDNRB was selected, and the expression was detected using immunohistochemistry in 33 ACC samples (including 6 clinical tumor stage 1 [T1] patients, 13 T2 patients, 9 T3 patients, and 5 T4 patients) and 20 adjacent glands. Interaction between the EDNRB promoter region and histone H3 ly  ...[more]

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