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Differential DNA methylation profiles of coding and non-coding genes define hippocampal sclerosis in human temporal lobe epilepsy

ABSTRACT: Methylation profiling was carried using Methylated DNA immunoprecipitation coupled with CpG island plus promoter array for human tissue samples. The samples, i.e. immunoprecipitate & input after immunoprecipitation were deferentially labelled using Cy5 & Cy3 flourophores. These were subsequently hybridized on the arrays and thereafter washed and scanned. The samples used for this study Hippocampal tissue was scored according to the Watson hippocampal sclerosis grading system- Watson Grade 1 or 4. Control tissue (labelled as Control in disease staging) was obtained from the NICHD Brain and Tissue Bank for Developmental Disorders at the University of Maryland, Baltimore, MD.

INSTRUMENT(S): Scanning of was performed on an Axon 4000B scanner

ORGANISM(S): Homo sapiens

SUBMITTER: Sudipto Das 

PROVIDER: E-MTAB-3054 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Genome-wide DNA methylation analysis of neuroblastic tumors reveals clinically relevant epigenetic events and large-scale epigenomic alterations localized to telomeric regions.

Buckley Patrick G PG   Das Sudipto S   Bryan Kenneth K   Watters Karen M KM   Alcock Leah L   Koster Jan J   Versteeg Rogier R   Stallings Raymond L RL  

International journal of cancer 20110501 10

The downregulation of specific genes through DNA hypermethylation is a major hallmark of cancer, although the extent and genomic distribution of hypermethylation occurring within cancer genomes is poorly understood. We report on the first genome-wide analysis of DNA methylation alterations in different neuroblastic tumor subtypes and cell lines, revealing higher order organization and clinically relevant alterations of the epigenome. The methylation status of 33,485 discrete loci representing al  ...[more]

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