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Identification of circulation microRNAs correlated with human POCD development

ABSTRACT: The preoperative and 24h postoperative peripheral blood samples from 3 patients who were clinically diagnosed with POCD 7 days after surgery and who presented with an improvement of cognitive function 3 months later were used to a microRNA microarray analysis. The microarray results showed that, compared with the preoperative microRNA expression profile, there were a large number of abnormally down-regulated circulating miRNA molecules in the peripheral blood 24 h after surgery.

INSTRUMENT(S): Agilent Microarray Scanner, Agilent Bioanalyzer 2100

ORGANISM(S): Homo sapiens

SUBMITTER: shupeng liu

PROVIDER: E-MTAB-3187 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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MicroRNA-572 improves early post-operative cognitive dysfunction by down-regulating neural cell adhesion molecule 1.

Yu Xiya X Liu Shupeng S Li Jinbao J Fan Xiaohua X Chen Yuanjie Y Bi Xiaoying X Liu Shanrong S Deng Xiaoming X

PloS one 20150213 2

Post-operative cognitive dysfunction (POCD) is a commonly-seen postoperative complication in elderly patients. However, the underlying mechanisms of POCD remain unclear. miRNAs, which are reported to be involved in the pathogenesis of the nervous system diseases, may also affect POCD. In this study, miRNA microarray technology was used to analyze the circulating miRNA expression profile of POCD patients. Among the altered miRNAs, miR-572 had the greatest decrease, which was also verified in vivo ...[more]

PMID: 25680004

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