Ontology highlight
ABSTRACT:
ORGANISM(S): Homo Sapiens
SUBMITTER: Katleen De Preter
PROVIDER: E-MTAB-3205 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Clinical cancer research : an official journal of the American Association for Cancer Research 20150324 14
<h4>Purpose</h4>Activating ALK mutations are present in almost 10% of primary neuroblastomas and mark patients for treatment with small-molecule ALK inhibitors in clinical trials. However, recent studies have shown that multiple mechanisms drive resistance to these molecular therapies. We anticipated that detailed mapping of the oncogenic ALK-driven signaling in neuroblastoma can aid to identify potential fragile nodes as additional targets for combination therapies.<h4>Experimental design</h4>T ...[more]