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Novel isolation strategy to deliver pure fetal-origin and maternal- origin mesenchymal stem cell (MSC) populations from human term placenta

ABSTRACT: The placenta is an abundant source of mesenchymal stem/stromal cells (MSC). Although presumed of translationally-advantageous fetal origin, the literature instead suggests a high incidence of either contaminating or pure maternal MSC. Despite definitional criteria that MSC are CD34ÌÛ, increasing evi- dence suggests that fetal MSC may be CD34 positive in vivo. We flow sorted term placental digests based on CD34Ì_ expression and exploited differential culture media to isolate separately pure fetal and maternal MSC populations. This method has considerable translational implications, in particular to clinical trials underway with ‰ÛÏplacental‰Û MSC of uncertain or decidual origin.

ORGANISM(S): Homo sapiens

SUBMITTER: Jatin Patel 

PROVIDER: E-MTAB-3229 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Novel isolation strategy to deliver pure fetal-origin and maternal-origin mesenchymal stem cell (MSC) populations from human term placenta.

Patel J J   Patel J J   Shafiee A A   Wang W W   Fisk N M NM   Khosrotehrani K K  

Placenta 20140910 11

The placenta is an abundant source of mesenchymal stem/stromal cells (MSC). Although presumed of translationally-advantageous fetal origin, the literature instead suggests a high incidence of either contaminating or pure maternal MSC. Despite definitional criteria that MSC are CD34-, increasing evidence suggests that fetal MSC may be CD34 positive in vivo. We flow sorted term placental digests based on CD34+ expression and exploited differential culture media to isolate separately pure fetal and  ...[more]

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