Pancreatic beta cell identity is maintained by DNA methylation-mediated repression of Arx
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Model-G2505B US23502366
ORGANISM(S): Mus musculus
SUBMITTER: Senta Georgia
PROVIDER: E-MTAB-3243 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Pancreatic β cell identity is maintained by DNA methylation-mediated repression of Arx.
Dhawan Sangeeta S Georgia Senta S Tschen Shuen-Ing SI Fan Guoping G Bhushan Anil A
Developmental cell 20110401 4
Adult pancreatic β cells can replicate during growth and after injury to maintain glucose homeostasis. Here, we report that β cells deficient in Dnmt1, an enzyme that propagates DNA methylation patterns during cell division, were converted to α cells. We identified the lineage determination gene aristaless-related homeobox (Arx), as methylated and repressed in β cells, and hypomethylated and expressed in α cells and Dnmt1-deficient β cells. We show that the methylated region of the Arx locus in ...[more]
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