Transcription profiling by array of yeast strains with different chromosome copy numbers
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ABSTRACT: Aneuploidy, the condition of having an abnormal number of chromosomes, is a hallmark of cancer cells. Recent work performed in yeast and mouse models suggests that aneuploidy interferes with cell proliferation and organism development. However, other recent experiments suggested that aneuploidy might play a positive role in tumor initiation and/or progression and in the emergence of chemotherapy as well as antibiotic resistances. Given its general deleterious effects on cellular fitness, how could aneuploidy be beneficial? In this set of experiments we plan to provide evidence that aneuploidy induces phenotypic variation through direct and indirect changes not only at the transcriptome but also at the proteome level.
ORGANISM(S): Saccharomyces cerevisiae
SUBMITTER: Ariel Paulson
PROVIDER: E-MTAB-325 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
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