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CD8+/CD103+ tumor-infiltrating lymphocytes are tumor-specific tissue-resident memory T cells and a prognostic factor for survival in lung cancer patients

ABSTRACT: We had previously demonstrated the role of CD103 integrin on lung tumor-infiltrating lymphocyte (TIL) clones in promoting specific TCR-mediated epithelial tumor cell cytotoxicity. However, the contribution of CD103 on intratumoral T-cell distribution and functions, and the prognosis significance of TIL subpopulations in non-small cell lung carcinoma (NSCLC) have thus far not been systematically addressed. Here we investigate the transcriptomic profil of these cell population, using PBMC cells as control.

ORGANISM(S): Homo sapiens

SUBMITTER: Guillaume Meurice

PROVIDER: E-MTAB-3266 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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CD8+CD103+ tumor-infiltrating lymphocytes are tumor-specific tissue-resident memory T cells and a prognostic factor for survival in lung cancer patients.

Djenidi Fayçal F Adam Julien J Goubar Aïcha A Durgeau Aurélie A Meurice Guillaume G de Montpréville Vincent V Validire Pierre P Besse Benjamin B Mami-Chouaib Fathia F

Journal of immunology (Baltimore, Md. : 1950) 20150227 7

We had previously demonstrated the role of CD103 integrin on lung tumor-infiltrating lymphocyte (TIL) clones in promoting specific TCR-mediated epithelial tumor cell cytotoxicity. However, the contribution of CD103 on intratumoral T cell distribution and functions and the prognosis significance of TIL subpopulations in non-small cell lung carcinoma (NSCLC) have thus far not been systematically addressed. In this study, we show that an enhanced CD103(+) TIL subset correlates with improved early s ...[more]

PMID: 25725111

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