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Long term exposure of HUVEC to plasma from preeclamptic versus normal pregnancies

ABSTRACT: Plasma from pregnant women were applied three days in three steps to HUVEC cells. RNAs were isolated and prepared. Four pools of RNAs were obtained, two of them from cells exposed to preeclamptic plasma (2 and 3, corresponding to mild and severe preeclampsia, respectively) and two from cells exposed to normal plasma from pregnant women (five and five).

ORGANISM(S): Homo sapiens

SUBMITTER: Daniel VAIMAN 

PROVIDER: E-MTAB-3348 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Preeclamptic plasma induces transcription modifications involving the AP-1 transcriptional regulator JDP2 in endothelial cells.

Calicchio Rosamaria R   Buffat Christophe C   Mathieu Jacques R JR   Ben Salem Nour N   Mehats Celine C   Jacques Sébastien S   Hertig Alexandre A   Berkane Nadia N   Grevoul-Fresquet Julie J   Simeoni Umberto U   Peyssonnaux Carole C   Gavard Julie J   Gavard Julie J   Vaiman Daniel D   Miralles Francisco F  

The American journal of pathology 20131010 6

Preeclampsia is a pregnancy disorder characterized by hypertension and proteinuria. In preeclampsia, the placenta releases factors into the maternal circulation that cause a systemic endothelial dysfunction. Herein, we investigated the effects of plasma from women with preeclamptic and normal pregnancies on the transcriptome of an immortalized human umbilical vein endothelial cell line. The cells were exposed for 24 hours to preeclamptic or normal pregnancy plasma and their transcriptome was ana  ...[more]

PMID: 24120378

Publication: 1/2

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