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Transcription profiling by array of human uterine fibroids with normal karyotype and 12q14~15 rearrangements

ABSTRACT: 12q14~15 chromosomal rearrangements, specifically affecting the HMGA2 gene locus, are frequently observed in human uterine fibroids. Those fibroids are observed to show fast growth to a larger size compared to fibroids of normal karyotype. Since the HMGA2 gene is overexpressed, this study provides further insights in the development of uterine fibroids.

ORGANISM(S): Homo sapiens

SUBMITTER: Joerg Mueller

PROVIDER: E-MTAB-340 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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HMGA proteins regulate the expression of FGF2 in uterine fibroids.

Helmke Burkhard Maria BM Markowski Dominique Nadine DN Müller Marietta Henrike MH Sommer Anette A Müller Jörg J Möller Carsten C Bullerdiek Jörn J

Molecular human reproduction 20101006 2

In human fibroids genes encoding the high-mobility proteins containing the 'AT-hook' DNA-binding motif (HMGA) are frequently affected by non-random chromosomal rearrangements. Thus, the different proteins and their derivatives resulting from these genomic rearrangements can be assumed to be involved in the genesis of these tumors by activation of largely identical downstream pathways. Constructs encoding HMGA proteins and their relevant derivatives were overexpressed in human myometrial cells, a ...[more]

PMID: 20926602

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