Ontology highlight
ABSTRACT:
INSTRUMENT(S): Solexa 2G Genome Analyzer
ORGANISM(S): Homo sapiens
SUBMITTER: Alessandro Weisz
PROVIDER: E-MTAB-345 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
BMC genomics 20110114
<h4>Background</h4>Estrogen receptors alpha (ERα) and beta (ERβ) are transcription factors (TFs) that mediate estrogen signaling and define the hormone-responsive phenotype of breast cancer (BC). The two receptors can be found co-expressed and play specific, often opposite, roles, with ERβ being able to modulate the effects of ERα on gene transcription and cell proliferation. ERβ is frequently lost in BC, where its presence generally correlates with a better prognosis of the disease. The identif ...[more]