Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
DISEASE(S): mitochondrial disease
SUBMITTER: Curt Scharfe
PROVIDER: E-MTAB-346 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Wang Wenyi W Shen Peidong P Thiyagarajan Sreedevi S Lin Shengrong S Palm Curtis C Horvath Rita R Klopstock Thomas T Cutler David D Pique Lynn L Schrijver Iris I Davis Ronald W RW Mindrinos Michael M Speed Terence P TP Scharfe Curt C
Nucleic acids research 20100915 1
A common goal in the discovery of rare functional DNA variants via medical resequencing is to incur a relatively lower proportion of false positive base-calls. We developed a novel statistical method for resequencing arrays (SRMA, sequence robust multi-array analysis) to increase the accuracy of detecting rare variants and reduce the costs in subsequent sequence verifications required in medical applications. SRMA includes single and multi-array analysis and accounts for technical variables as w ...[more]