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Gene Expression of human bladder cancer cell line RT112 and Gemcitabine Resistant Bladder Cancer cell line RT112-Gr

ABSTRACT: In this research, Human OneArray Microarray analysis was performed to obtain broad spectrum information about the genes differentially expressed in human bladder cancer cell line RT112 and Gemcitabine Resistant Bladder Cancer cell line RT112-Gr.

ORGANISM(S): Homo sapiens

SUBMITTER: sentai ding

PROVIDER: E-MTAB-3495 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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A Potent Chemotherapeutic Strategy with Eg5 Inhibitor against Gemcitabine Resistant Bladder Cancer.

Sun Liang L Lu Jiaju J Niu Zhihong Z Ding Kejia K Bi Dongbin D Liu Shuai S Li Jiamei J Wu Fei F Zhang Hui H Zhao Zuohui Z Ding Sentai S

PloS one 20151210 12

Development of resistance to gemcitabine is a major concern in bladder cancer therapy, and the mechanism remains unclear. Eg5 has been recently identified as an attractive target in cancer chemotherapy, so novel targeted chemotherapy with Eg5 inhibitor is expected to improve the anticancer effect in gemcitabine-resistant bladder cancer. In this research, RT112-Gr cells were 350-fold less sensitive to gemcitabine than the parental cell lines, while KU7-Gr cells were 15-fold less sensitive to gemc ...[more]

PMID: 26658059

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