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Genomic modulators of gene expression in human neutrophils

ABSTRACT: Neutrophils form the most abundant leukocyte subset and are central to many disease processes. Technical challenges in transcriptomic profiling have prohibited genetical genomic approaches to date. Here, we map expression quantitative trait loci (eQTL) in peripheral blood CD16+ neutrophils from 101 healthy European adults. This dataset includes expression data from neutrophils. The genotypes and expression data from monocytes can be found in E-MTAB-2232 - Genetics of gene expression across innate immune stimulation in primary monocytes.

ORGANISM(S): Homo sapiens

SUBMITTER: Julian Knight

PROVIDER: E-MTAB-3536 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Genomic modulators of gene expression in human neutrophils.

Naranbhai Vivek V Fairfax Benjamin P BP Makino Seiko S Humburg Peter P Wong Daniel D Ng Esther E Hill Adrian V S AV Knight Julian C JC

Nature communications 20150707

Neutrophils form the most abundant leukocyte subset and are central to many disease processes. Technical challenges in transcriptomic profiling have prohibited genomic approaches to date. Here we map expression quantitative trait loci (eQTL) in peripheral blood CD16+ neutrophils from 101 healthy European adults. We identify cis-eQTL for 3281 neutrophil-expressed genes including many implicated in neutrophil function, with 450 of these not previously observed in myeloid or lymphoid cells. Paired ...[more]

PMID: 26151758

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