Unknown,Transcriptomics,Genomics,Proteomics

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Population-based whole-genome bisulfite sequencing in multiple human tissues


ABSTRACT: Analysis of human population methylome variation in adipose tissue and whole blood at single-site resolution by whole genome bisulfite sequencing.

INSTRUMENT(S): Illumina HiSeq 2000

ORGANISM(S): Homo sapiens

SUBMITTER: Elin Grundberg 

PROVIDER: E-MTAB-3549 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications


<h4>Background</h4>CpG methylation variation is involved in human trait formation and disease susceptibility. Analyses within populations have been biased towards CpG-dense regions through the application of targeted arrays. We generate whole-genome bisulfite sequencing data for approximately 30 adipose and blood samples from monozygotic and dizygotic twins for the characterization of non-genetic and genetic effects at single-site resolution.<h4>Results</h4>Purely invariable CpGs display a bimod  ...[more]

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