Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

Transcription profiling by array of mouse wild type and Nkx2.2 knock-out embryos


ABSTRACT: The goal: Investigate the genes differentlly expressed during pancreas development. The model: The Nkx2.2 null allele was generated using standard homologous recombination in ES cells. The Pgk:NeoR cassette was inserted into a 4.4 Kb deletion of the Nkx2.2 genomic locus, effectively deleting both coding exons. The mice are maintained on a Swiss Black strain background.

ORGANISM(S): Mus musculus

SUBMITTER: Lori Sussel 

PROVIDER: E-MTAB-356 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

altmetric image

Publications

Novel computational analysis of protein binding array data identifies direct targets of Nkx2.2 in the pancreas.

Hill Jonathon T JT   Anderson Keith R KR   Mastracci Teresa L TL   Kaestner Klaus H KH   Sussel Lori L  

BMC bioinformatics 20110225


<h4>Background</h4>The creation of a complete genome-wide map of transcription factor binding sites is essential for understanding gene regulatory networks in vivo. However, current prediction methods generally rely on statistical models that imperfectly model transcription factor binding. Generation of new prediction methods that are based on protein binding data, but do not rely on these models may improve prediction sensitivity and specificity.<h4>Results</h4>We propose a method for predictin  ...[more]

Similar Datasets

| PRJNA316849 | ENA
2015-02-03 | E-MTAB-3350 | biostudies-arrayexpress
2015-01-29 | E-MTAB-3349 | biostudies-arrayexpress
2009-11-05 | E-CBIL-44 | biostudies-arrayexpress
2010-03-03 | E-MTAB-152 | biostudies-arrayexpress
2017-01-09 | GSE80444 | GEO
2022-05-24 | GSE174228 | GEO
2019-11-01 | GSE73921 | GEO
2020-09-30 | GSE73664 | GEO
2015-02-24 | E-MTAB-3357 | biostudies-arrayexpress