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Sample Validation Study_microarrays

ABSTRACT: Sample Validation Study_microarrays

ORGANISM(S): Homo sapiens

DISEASE(S): Non-CF

SUBMITTER: Varrie Ogilvie

PROVIDER: E-MTAB-360 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Changes in transcriptome of native nasal epithelium expressing F508del-CFTR and intersecting data from comparable studies.

Clarke Luka A LA Sousa Lisete L Barreto Celeste C Amaral Margarida D MD

Respiratory research 20130328

<h4>Background</h4>Microarray studies related to cystic fibrosis (CF) airway gene expression have gone some way in clarifying the complex molecular background of CF lung diseases, but have made little progress in defining a robust "molecular signature" associated with mutant CFTR expression. Disparate methodological and statistical analyses complicate comparisons between independent studies of the CF transcriptome, and although each study may be valid in isolation, the conclusions reached differ ...[more]

PMID: 23537407

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