Browse
Submit Data
Databases
API
Help

Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

38 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Sequencing of total RNA in mouse ileum to evaluate effect of IFNg and Akkermansia muciniphila on host gene expression

ABSTRACT: Total RNA from ileum of three groups of mice are sequenced. The three groups are 1. wild type mice. 2. mice with IFNg gene knockout. 3. IFNg gene knockout mice after colonization of Akkermansia muciniphila

INSTRUMENT(S): Illumina HiSeq 2000

ORGANISM(S): Mus musculus

SUBMITTER: xiaoxi dong

PROVIDER: E-MTAB-3633 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

ACCESS DATA

Json Xml

Similar Datasets

Effect of interferon-gamma (IFNg) deficiency in murine small intestine (ileum)

Project description:Gene expression profiling of C57Bl/6 wild type and IFNg-deficient whole ileum at 8 weeks of age 5 wild type control, 5 IFNg knockout

2016-07-16 | E-GEOD-69635 | biostudies-arrayexpress

Sequencing of total RNA in mouse ileum to evaluate effect of IFNg and Akkermansia muciniphila on host gene expression

Project description:Sequencing of total RNA in mouse ileum to evaluate effect of IFNg and Akkermansia muciniphila on host gene expression

| PRJEB9615 | ENA

effect of IFNg and Akkermansia muciniphila on mouse gut microbiome composition

Project description:effect of IFNg and Akkermansia muciniphila on mouse gut microbiome composition

| PRJEB9551 | ENA

Akkermansia muciniphila Membrane Protein Improves Cognitive Function in Aged Mice by Reducing IL-6 Expression

Project description:We implemented transcriptomic analyses of blood and hippocampus of old mice treated with Akkermansia muciniphila Membrane Protein for 8 weeks.

2023-08-25 | GSE162123 | GEO

Multi-omics analysis reveals gut-brain interactions mediating the anti-obesity effect of Akkermansia muciniphila

Project description:Previous studies have implicated a causal role for the gut bacterium Akkermansia muciniphila in counteracting diet-induced obesity and metabolic dysfunctions. However, a systems level understanding of the molecular mechanisms underlying the anti-obesogenic effect of A. muciniphila is lacking. Using fructose-induced obese mice as a model, we carried out multiomics studies to investigate the molecular cascades mediating the effect of A. muciniphila. We found that A. muciniphila colonization in fructose-induced obese mice triggered significant shifts in gut microbiota composition as well as alterations in numerous gut and plasma metabolites and gene expression in the hypothalamus. Among these, we found that the metabolite oleoyl-ethanolamide in the gut and circulation and hypothalamic oxytocin are the key regulators of gut-brain interactions that underlie the A. muciniphila anti-obesity effect. Our multiomics investigation elucidates the molecular regulators and pathways involved in the communication between A. muciniphila in the gut and hypothalamic neurons that counter fructose-induced obesity .

2022-09-03 | GSE212491 | GEO

Interferon-gamma timecourse in IFNg-/- and SOCS1-/-IFNg-/- mouse livers

Project description:Timecourse analysis of Interferon-Gamma (IFNg) signalling in mice deficient for IFNg or both IFNg and Suppressor of Cytokine Signalling-1 (SOCS1). Keywords: time course expression analysis

2006-02-14 | GSE4232 | GEO

Effect of interferon-gamma (IFNg) deficiency in murine small intestine (ileum)

Project description:Gene expression profiling of C57Bl/6 wild type and IFNg-deficient whole ileum at 8 weeks of age

2016-07-16 | GSE69635 | GEO

Mass spectrometry identification of Akkermansia muciniphila -Caco2 cells interaction proteins

Project description:Akkermansia muciniphila is recognized as a promising probiotic that improves the symptoms of a variety of diseases. However, the role and mechanism of A. muciniphila in regulating intestinal homeostasis remain to be explored. Here, we discovered that A. muciniphila was dramatically increased during colitis recovery, and its colonization greatly increased goblet cells to protect the intestinal barrier in mice. Amuc_0904, a previously uncharacterized A. muciniphila outer membrane protein, was identified to induce goblet cell differentiation.We want to find the receptors that 904 interacts with cells to explore the detailed mechanism.

2024-09-02 | PXD055466 | Pride

IFNg+ vs IFNg- Treg

Project description:Gene expression studies comparing IFNg+ Tregs versus IFNg- Tregs from human peripheral blood Ex vivo sorted Tregs (CD25highCD127neg) were stimulated for 4 hours and IFNg-secreting cells were detected by a IFNg-capture kit. The samples were resorted based on IFNg expression.

2016-07-01 | E-GEOD-71274 | biostudies-arrayexpress

Brd4 knockout colonic epithelial organoids are partially resistant to IFNg-induced cell death.

Project description:To identify the role of Brd4 in colorectal cancer (CRC) development , we performed Sleeping Beauty (SB) transposon mutagenesis in mice. We identified several candidate genes including Brd4. To provide functional validation, we knocked out Brd4 in mouse tumor organoids carrying an activating KrasG12D, and an inactivating ApcD716 allele, and performed RNAseq. Brd4 knockout colonic organoids showed deregulation of genes in IFNg signaling. We treated Brd4 knockout organoids with IFNg and found that Brd4 konckout organoids showed partial resistance to IFNg-induce cell death. The mechanism may explain the function of Brd4 in colon cancer development.

2024-11-24 | GSE248821 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data