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Varicella-Zoster Virus (VZV) quiescent and productive infection of neurons derived from human embryonic stem cells

ABSTRACT: quiescent and productive infection of varicella zoster virus in human embryonic stem stem cell-derived neurons

INSTRUMENT(S): Illumina HiSeq 2500

ORGANISM(S): Homo sapiens

SUBMITTER: amos markus

PROVIDER: E-MTAB-3635 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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An in vitro model of latency and reactivation of varicella zoster virus in human stem cell-derived neurons.

Markus Amos A Lebenthal-Loinger Ilana I Yang In Hong IH Kinchington Paul R PR Goldstein Ronald S RS

PLoS pathogens 20150604 6

Varicella zoster virus (VZV) latency in sensory and autonomic neurons has remained enigmatic and difficult to study, and experimental reactivation has not yet been achieved. We have previously shown that human embryonic stem cell (hESC)-derived neurons are permissive to a productive and spreading VZV infection. We now demonstrate that hESC-derived neurons can also host a persistent non-productive infection lasting for weeks which can subsequently be reactivated by multiple experimental stimuli. ...[more]

PMID: 26042814

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