T(15;21) translocation leading to the concurrent downregulation of RUNX1 and its transcription factor partner genes SIN3A and TCF12 in myeloid disorders
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ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Massimo Carella
PROVIDER: E-MTAB-3782 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
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Project description:We report on two novel t(15;21) alterations [t(15;21)(q24;q22) and t(15;21)(q21;q22)], which led to concurrent disruption of RUNX1 and two translocation partner genes encoding for transcription factors (SIN3A, TCF12)
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Project description:We report on two novel t(15;21) alterations [t(15;21)(q24;q22) and t(15;21)(q21;q22)], which led to concurrent disruption of RUNX1 and two translocation partner genes encoding for transcription factors (SIN3A, TCF12) Examination of four different patients with myeloid disorders. 2 out of 4 have been analyzed by means RNAseq
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