Browse
Submit Data
Databases
API
Help

Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Genomics and epigenetics: A study of ependymomas in pediatric patients

ABSTRACT: To the methylation pattern in pediatric ependymomas by methylation were performed through the Agilent platform.

INSTRUMENT(S): 2100 Bioanalyzer Agilent, Intel Core 2 Duo E8500 3.16 GHz or equivalent

ORGANISM(S): Homo sapiens

SUBMITTER: Monserrat Pérez Ramírez

PROVIDER: E-MTAB-3846 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

ACCESS DATA

Json Xml

Similar Datasets

Genomics and epigenetics: A study of ependymomas in pediatric patients

Project description:In this work the objective is identify chromosomal alterations in ependymoma in pediatric patients, we used CGH microarray were performed through the Agilent platform.

2016-03-15 | E-MTAB-3850 | biostudies-arrayexpress

Genomics and epigenetics: A study of ependymomas in pediatric patients

Project description:This worck identify gene expression changes in pediatric ependymomas by microarray gene expression were performed through the Agilent platform.

2016-03-15 | E-MTAB-3845 | biostudies-arrayexpress

Pediatric pineal germinomas: Epigenetic and genomic approach (methylation profiling)

Project description:We identify and correlate chromosomal alterations, methylation patterns and gene expression in pediatric pineal germinomas. Due the low incidence of pineal germinoma, there is insufficient molecular data related to chromosomal alterations, methylation patterns and genetic expression that may help understand the changes that influence tumor development. In addition, at present, the diagnosis of this tumor in childhood is challenging because of its location and cellular origin, which is why our aim was to understand and to identify possible molecular biomarkers to provide information on the diagnosis and tumor development. Tumor biopsies were obtained from pediatric patients of 0 to 16 years of age, they were subsequently evaluated by histopathological analysis. Sample selection was based on the percentage of tumor cells present in the tumor samples, processing the samples containing the lowest 70% and 80% tumor cells, respectively.

2016-11-26 | E-MTAB-5107 | biostudies-arrayexpress

Pediatric pineal germinomas: Epigenetic and genomic approach (comparative genomic hybridization)

2016-11-26 | E-MTAB-5106 | biostudies-arrayexpress

Epigenomic Alterations Define Lethal CIMP positive Ependymomas of Infancy

Project description:Ependymomas are common childhood brain tumors that occur throughout the nervous system, but are most common in the pediatric hindbrain. Current standard therapy comprises surgery and radiation, but not cytotoxic chemotherapy as it does not further increase survival. Whole-genome and whole-exome sequencing of 47 hindbrain ependymomas reveals an extremely low mutation rate, and zero significant recurrent somatic SNVs. While devoid of recurrent SNVs and focal copy number aberrations, poor prognosis hindbrain ependymomas exhibit a CpG island methylator phenotype (CIMP). Transcriptional silencing driven by CpG methylation converges exclusively on targets of the polycomb repressor complex 2 (PRC2) that represses expression of differentiation genes through tri-methylation of H3K27. CIMP-positive (CIMP+) hindbrain ependymomas are responsive to clinical drugs that target either DNA or H3K27 methylation both in vitro and in vivo. We conclude that epigenetic modifiers are the first rational therapeutic candidates for this deadly malignancy, which is epigenetically de-regulated but genetically bland. 10 primary posterior fossa ependymomas have been analyzed

2014-03-15 | E-GEOD-55920 | biostudies-arrayexpress

Epigenomic Alterations Define Lethal CIMP positive Ependymomas of Infancy

2014-03-15 | GSE55920 | GEO

Low H3K27me3 define poorly prognostic pediatric posterior fossa ependymomas

Project description:A subgroup of Posterior fossa ependymomas show reduced H3K27me3 are more invasive, exhibit poor prognosis and epigenetically deregulated genes converge on radial glial factors, suggesting developing cerebellar radial glia as candidate cells-of-origin.

2016-11-23 | GSE89451 | GEO

DNA hypomethylation define poorly prognostic pediatric posterior fossa ependymomas

Project description:A subset of genomically silent childhood posterior fossa ependymomas show reduced H3K27me3, global DNA hypomethylation, are more invasive, exhibit poor prognosis and epigenetically deregulated genes converge on radial glial factors, suggesting developing cerebellar radial glia as candidate cells-of-origin.

2016-11-28 | GSE87779 | GEO

Epigenomic Alterations Define Lethal CIMP-positive Ependymomas of Infancy

Project description:1) Illumina 450K methylation profiles-48 posterior fossa ependymomas

2014-03-25 | GSE45353 | GEO

Epigenomic Alterations Define Lethal CIMP-positive Ependymomas of Infancy

Project description:1) Illumina 450K methylation profiles-48 posterior fossa ependymomas NA

2014-03-25 | E-GEOD-45353 | biostudies-arrayexpress