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Unknown,Transcriptomics,Genomics,Proteomics

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ZEA

ABSTRACT: This is a cell culture based study to asses the impact of ZEA (Zearalenone) and E. coli co-contamination on IPEC cells, these is a normal epithelial cell line isolated from a new born piglet. ZEA is a mycotoxin with a negative impact in human health. The microarray is a custom Agilent Technology array slide with the AMAID: 05685.

ORGANISM(S): Sus scrofa

SUBMITTER: Cornelia Braicu

PROVIDER: E-MTAB-3885 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Zearalenone mycotoxin affects immune mediators, MAPK signalling molecules, nuclear receptors and genome-wide gene expression in pig spleen.

Pistol Gina Cecilia GC Braicu Cornelia C Motiu Monica M Gras Mihail Alexandru MA Marin Daniela Eliza DE Stancu Mariana M Calin Loredana L Israel-Roming Florentina F Berindan-Neagoe Ioana I Taranu Ionelia I

PloS one 20150526 5

The toxicity of zearalenone (ZEA) was evaluated in swine spleen, a key organ for the innate and adaptative immune response. Weaned pigs were fed for 18 days with a control or a ZEA contaminated diet. The effect of ZEA was assessed on wide genome expression, pro- (TNF-α, IL-8, IL-6, IL-1β, IFN-γ) and anti-inflammatory (IL-10, IL-4) cytokines, other molecules involved in inflammatory processes (MMPs/TIMPs), as well as signaling molecules, (p38/JNK1/JNK2-MAPKs) and nuclear receptors (PPARγ/NFkB/AP- ...[more]

PMID: 26011631

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