Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Elarouci Nabila
PROVIDER: E-MTAB-3903 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Kamoun Aurélie A Idbaih Ahmed A Dehais Caroline C Elarouci Nabila N Carpentier Catherine C Letouzé Eric E Colin Carole C Mokhtari Karima K Jouvet Anne A Uro-Coste Emmanuelle E Martin-Duverneuil Nadine N Sanson Marc M Delattre Jean-Yves JY Figarella-Branger Dominique D de Reyniès Aurélien A Ducray François F
Nature communications 20160419
Oligodendroglial tumours (OT) are a heterogeneous group of gliomas. Three molecular subgroups are currently distinguished on the basis of the IDH mutation and 1p/19q co-deletion. Here we present an integrated analysis of the transcriptome, genome and methylome of 156 OT. Not only does our multi-omics classification match the current classification but also reveals three subgroups within 1p/19q co-deleted tumours, associated with specific expression patterns of nervous system cell types: oligoden ...[more]