Browse
Submit Data
Databases
API
Help

Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Whole genome sequencing of Drosophila spontaneous midgut neoplasias and control tissues.

ABSTRACT: Whole genome sequencing was performed in order to uncover genomic mutations present in spontaneous neoplasias present in aged male midguts. DNA was extracted from neoplasias (marked by ProsGal4 UAS-GFP), adjacent tissue and head of the same fly. The DNA library was prepared using the DNA Nano protocol from Illumina and 2X125 bp paired-end Illumina Hi-Seq was performed by Fasteris, SA (Geneva, CHE).

INSTRUMENT(S): Illumina HiSeq 2500

ORGANISM(S): Drosophila melanogaster

SUBMITTER: Allison Bardin

PROVIDER: E-MTAB-3917 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

ACCESS DATA

Json Xml

Similar Datasets

Compilation of expression profiles distinct thyroid neoplasias

Project description:A cohort of distinct thyroid neoplasias was hybridized onto the Affymetrix U95 GeneChip

2012-06-01 | GSE29315 | GEO

Whole genome sequencing of Drosophila spontaneous midgut neoplasias and control tissues.

Project description:Whole genome sequencing of Drosophila spontaneous midgut neoplasias and control tissues.

| PRJEB10938 | ENA

Compilation of expression profiles distinct thyroid neoplasias

Project description:A cohort of distinct thyroid neoplasias was hybridized onto the Affymetrix U95 GeneChip We profiled the gene expression of a cohort of 9 Hurthle cell adenomas, 17 follicular adenomas, 9 follicular thyroid carcinomas, 13 follicular variants of papillary thyroid carcinomas, 6 Hashimoto throiditis, 8 thyroid hyperplasias and 9 papillary thyroid carcinomas.

2012-05-31 | E-GEOD-29315 | biostudies-arrayexpress

Pol III transcribed genes, RNA-Seq, female fruit fly, midgut

Project description:RNA-Seq of small (Pol III-transcribed) RNAs in midguts of female fruit flies, Pol III heterozygous mutant versus wild-type

2024-08-26 | GSE232719 | GEO

Integrated miRNAs profiling, DNA methylation, and RNA expression in gastroenteropancreatic neuroendocrine neoplasias

Project description:Integrated miRNAs profiling, DNA methylation, and RNA expression in gastroenteropancreatic neuroendocrine neoplasias

| PRJNA870477 | ENA

Integrated miRNAs profiling, DNA methylation, and RNA expression in gastroenteropancreatic neuroendocrine neoplasias [methylation]

Project description:Integrated miRNAs profiling, DNA methylation, and RNA expression in gastroenteropancreatic neuroendocrine neoplasias [methylation]

| PRJNA870486 | ENA

Integrated miRNAs profiling, DNA methylation, and RNA expression in gastroenteropancreatic neuroendocrine neoplasias [mRNA]

Project description:Integrated miRNAs profiling, DNA methylation, and RNA expression in gastroenteropancreatic neuroendocrine neoplasias [mRNA]

| PRJNA870488 | ENA

Integrated miRNAs profiling, DNA methylation, and RNA expression in gastroenteropancreatic neuroendocrine neoplasias [miRNA]

Project description:Integrated miRNAs profiling, DNA methylation, and RNA expression in gastroenteropancreatic neuroendocrine neoplasias [miRNA]

| PRJNA870489 | ENA

Transcription profiling of Drosophila third instar larvae midgut

Project description:Oligoarray analysis was used to determine the number and nature of genes expressed in third-instar Drosophila melanogaster larval midguts. The majority of transcripts were associated with protein synthesis and metabolism. Serine proteases were the main proteolytic enzymes detected. Experiment Overall Design: Three replicates for each sample. We used Affy chip Drosophila 1.

2008-06-16 | E-GEOD-9879 | biostudies-arrayexpress

A shared transcriptional program in early breast neoplasias despite genetic and clinical distinctions

Project description:The earliest recognizable stages of breast neoplasia are lesions that represent a heterogeneous collection of epithelial proliferations currently classified based on morphology. Their role in the development of breast cancer is not well understood but insight into the critical events at this early stage will improve efforts in breast cancer detection and prevention. These microscopic lesions are technically difficult to study so very little is known about their molecular alterations. To characterize the transcriptional changes of early breast neoplasia, we sequenced 3'- end enriched RNAseq libraries from formalin-fixed paraffin-embedded tissue of early neoplasia samples and matched normal breast and carcinoma samples from 25 patients. We find that gene expression patterns within early neoplasias are distinct from both normal and breast cancer patterns and identify a pattern of pro-oncogenic changes, including elevated transcription of ERBB2, FOXA1, and GATA3 at this early stage. We validate these findings on a second independent gene expression profile data set generated by whole transcriptome sequencing. Measurements of protein expression by immunohistochemistry on an independent set of early neoplasias confirms that ER pathway regulators FOXA1 and GATA3, as well as ER itself, are consistently upregulated at this early stage. The early neoplasia samples also demonstrate coordinated changes in long non-coding RNA expression and microenvironment stromal gene expression patterns. This study is the first examination of global gene expression in early breast neoplasia, and the genes identified here represent candidate participants in the earliest molecular events in the development of breast cancer.

2014-05-04 | GSE47462 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data