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Characterization of the miRNA profile of activated or apoptotic lymphocytes and corresponding released microvesicles in normal healthy donors and systemic lupus erythematosus (SLE) patients.

ABSTRACT: In this experiment, the miRNA profile of microvesicles (MV) released from activated or apoptotic (UV-B treated) T-lymphocytes and their cells of origin was analyzed in both samples obtained from normal healthy donors and systemic lupus erythematosus (SLE) patients. Therefore in short, RNA was isolated of activated and apoptotic (UV-B treated) T-Lymphocytes and corresponding MV of normal healthy individuals and systemic lupus erythematosus (SLE) patients. Samples of four donors each were pooled. The aim was to characterize the miRNA profile of MV dependent on different release stimuli and compare their miRNA-profile to their cells of origin.

ORGANISM(S): Homo sapiens

SUBMITTER: Laura ClaÃen

PROVIDER: E-MTAB-3944 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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