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Reduced representation of bisulfite sequencing (RRBS) of murine T-cell acute lymphoblastic leukemia (T-ALL) cells to investigate DNA methylation profiling of lymphocyte deficient for Tet2 and mutated for DNMT3A

ABSTRACT: T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive proliferation of T-lymphocytes usually associated with oncogenic activation of NOTCH1 signaling. Using a bone marrow transplantation approach, we have modeled murine CD4+ CD8+ T-ALL by overexpressing DNMT3A R882H in Tet2-/- multipotent progenitors. T-ALL derived from NOTCH1 L1601PdelP Tet2-/-, NOTCH1 L1601PdelP Tet2+/+ or TCL1A progenitors were used for comparison, as well as normal Tet2+/+ and Tet2-/- CD4+ CD8+ double positive (DP) thymocytes.

INSTRUMENT(S): Illumina HiSeq 2000

ORGANISM(S): Mus musculus

SUBMITTER: Dessen Philippe

PROVIDER: E-MTAB-4159 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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