Unknown,Transcriptomics,Genomics,Proteomics

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Bronchiolar progenitors and club cells in mouse lung

ABSTRACT: Gene expression patterns of bronchiolar progenitors and club cells in mouse lung were examined by microarray experiments. Although it has not yet been fully characterized, a subset of epithelial cells lining bronchioles are best understood as bronchiolar progenitors that self-renew over the long term and that can differentiate into more differentiated club cells and ciliated cells. The bronchiolar progenitors are distinct from club cells and characteristically express the alveolar type 2 cell marker, prosurfactant protein C, with lower levels of club cell secretory protein/Scgb1a1. There are also functional differences between them; while club cells can be depleted by naphthalene because of the abundance of cytochrome P450 enzyme Cyp2f2, bronchiolar progenitors are resistant to naphthalene-induced depletion because of defects in the enzyme.

ORGANISM(S): Mus musculus

SUBMITTER: Toshiaki Kikuchi

PROVIDER: E-MTAB-4460 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Bronchiolar progenitors and club cells in mouse lung

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