Gene expression profiling after vaccination with the RTS,S candidate malaria vaccine in a controlled human malaria infection study

ABSTRACT: RTS,S is the sole candidate vaccine shown to provide protection against infection to malaria-naive adults challenged with mosquito-borne homologous falciparum malaria and protection against infection and clinical and severe disease to volunteers in malaria-endemic Africa who were exposed to diverse Plasmodium falciparum strains. In this experiment we profiled gene expression in PBMCs after vaccination with the RTS,S candidate malaria vaccine in a controlled human malaria infection study. Subjects were vaccinated with three doses of the RTS,S candidate malaria vaccine. Blood samples for PBMC isolation and subsequent gene expression analysis were taken on day 0 (0m), day of the third vaccination (8w), 1 day post third vaccination (8w1d), 3 days post third vaccination (8w3d), the day of the

ORGANISM(S): Homo sapiens

SUBMITTER: Robert van den Berg 

PROVIDER: E-MTAB-4629 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress