Transcriptional profiling of brain from WT, AAV9-Ids or Null-treated MPSII mice.
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ABSTRACT: The experiment evaluates the therapeutic effect brain injected AAV9-IDS (Adeno-associated virus 9 encoding IDS enzyme) treatment in a mouse model of Mucopolysaccharidosis Type II (MPSII). Microarrays were performed in order to compare the transcriptional profiling after the treatment. Three groups were analyzed, wild type (WT) mice, MPSII mice treated with AAV-NULL (AAV vector alone) and MPSII mice treated with AAV-IDS (vector encoding IDS enzyme). Four months after vector administration (at 6 months of age), animals were sacrificed and tissues were harvested and processed. RNA isolated from the encephalon of three groups of mice was analysed using the Affimetrix® microarray platform
ORGANISM(S): Mus musculus
SUBMITTER: Miquel Garcia
PROVIDER: E-MTAB-4728 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
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