In vitro expression in FGFR inhibitor sensitive and resistant cell lines
Ontology highlight
ABSTRACT: The challenge of developing effective pharmacodynamic biomarkers for pre-clinical and clinical testing of FGFR signalling inhibition is significant. Assays that rely on the measurement of phospho-protein epitopes can be limited by the availability of effective antibody detection reagents. Transcript profiling enables accurate quantification of many biomarkers and a broader representation of pathway modulation. To identify dynamic transcript biomarkers of FGFR signalling inhibition by AZD4547, a potent inhibitor of FGF receptor 1, 2 and 3, a gene expression profiling study was performed in FGFR2 amplified drug sensitive tumour cell lines.
ORGANISM(S): Homo sapiens
SUBMITTER: Oona Delpeuch
PROVIDER: E-MTAB-4749 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
ACCESS DATA