Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Chuan-Yuan Li
PROVIDER: E-MTAB-4771 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Li Fang F Liu Xinjian X Sampson John H JH Bigner Darell D DD Li Chuan-Yuan CY
Cancer research 20160630 17
Cancer stem-like cells (CSC) are thought to drive brain cancer, but their cellular and molecular origins remain uncertain. Here, we report the successful generation of induced CSC (iCSC) from primary human astrocytes through the expression of defined genetic factors. Combined transduction of four factors, Myc, Oct-4, p53DD, and Ras, induced efficient transformation of primary human astrocytes into malignant cells with powerful tumor-initiating capabilities. Notably, transplantation of 100 transd ...[more]