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A transit amplifying population underpins the efficient regenerative capacity of the testis

ABSTRACT: To study the adult population of spermatogonial stem cells marked with the expression of Miwi2, we generated the Miwi2-Tomato reporter knock-in allele. To further explore the molecular identity of Miwi2-TomPos spermatogonia, we performed comparative gene expression analysis between two population hierarchically related, an upstream population of Miwi2-TomHi c-KitNeg spermatogonia and their Miwi2-TomHi c-KitPos descendants. The analysis revealed enrichment for many genes that have been associated with SSC/SPC (Spermatogonial Stem Cells/ Spermatogonial Precursor Cells) phenotype or function.

ORGANISM(S): Mus musculus

SUBMITTER: Claudia Carrieri

PROVIDER: E-MTAB-4828 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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