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RNA-Seq in liver of Tc1 mice carrying human chromosome 21 passaged through either the female or male germline

ABSTRACT: This study aims to investigate whether the passage of human chromosome 21 through the mouse male germline results in changes in the transcriptional deployment of the exogenous chromosome in the offspring generation. We used the Tc1 mouse model that stably carries almost an entire copy of human chromosome 21 and profiled transcription in the livers of male- and female-germline derived Tc1 mice using strand-specific total RNA-Seq

INSTRUMENT(S): Illumina HiSeq 2000

ORGANISM(S): Mus musculus

SUBMITTER: Duncan Odom

PROVIDER: E-MTAB-4912 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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