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Bone marrow-derived and resident liver macrophages display unique transcriptomic signatures but similar biological functions

ABSTRACT: Liver macrophages play a major role in the control of infections in the liver and in the pathology associated with chronic liver diseases. It was recently shown that liver macrophages can have two different origins, however, the extent to which these populations are functionally distinct remains to be fully addressed. In this study, we compare the gene expression profile of liver resident and bone marrow derived liver macrophages in mouse, 6 weeks after total body irradiation and bone marrow transplantation.

ORGANISM(S): Mus musculus

SUBMITTER: Lynette Beattie

PROVIDER: E-MTAB-4954 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Bone marrow-derived and resident liver macrophages display unique transcriptomic signatures but similar biological functions.

Beattie Lynette L Sawtell Amy A Mann Jason J Frame Teija C M TCM Teal Bianca B de Labastida Rivera Fabian F Brown Najmeeyah N Walwyn-Brown Katherine K Moore John W J JWJ MacDonald Sandy S Lim Eng-Kiat EK Dalton Jane E JE Engwerda Christian R CR MacDonald Kelli P KP Kaye Paul M PM

Journal of hepatology 20160601 4

<h4>Background & aims</h4>Kupffer cells (KCs), the resident tissue macrophages of the liver, play a crucial role in the clearance of pathogens and other particulate materials that reach the systemic circulation. Recent studies have identified KCs as a yolk sac-derived resident macrophage population that is replenished independently of monocytes in the steady state. Although it is now established that following local tissue injury, bone marrow derived monocytes may infiltrate the tissue and diffe ...[more]

PMID: 27262757

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