Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Lynette Beattie
PROVIDER: E-MTAB-4954 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Beattie Lynette L Sawtell Amy A Mann Jason J Frame Teija C M TCM Teal Bianca B de Labastida Rivera Fabian F Brown Najmeeyah N Walwyn-Brown Katherine K Moore John W J JWJ MacDonald Sandy S Lim Eng-Kiat EK Dalton Jane E JE Engwerda Christian R CR MacDonald Kelli P KP Kaye Paul M PM
Journal of hepatology 20160601 4
<h4>Background & aims</h4>Kupffer cells (KCs), the resident tissue macrophages of the liver, play a crucial role in the clearance of pathogens and other particulate materials that reach the systemic circulation. Recent studies have identified KCs as a yolk sac-derived resident macrophage population that is replenished independently of monocytes in the steady state. Although it is now established that following local tissue injury, bone marrow derived monocytes may infiltrate the tissue and diffe ...[more]